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Pyrazoles As Potent Antimicrobial Agents   Harish Arora and Sandeep Jain

Pyrazoles As Potent Antimicrobial Agents

96 страниц. 2012 год.
LAP Lambert Academic Publishing
Pyrazole, one of the most important classes of heterocycles, has been the topic of research for thousands of researchers all over the world because of its wide spectrum activities like anti-inflammatory, antipyretic, analgesic, antimicrobial, antihypertensive, antiglaucoma, antioxidant, antidepressent, antiarthritic, neuroprotective, antidiabetic, anticancer, antitubercular, antiviral, and antialzheimer. Pyrazole is the core structural component present in Celecoxib, Deracoxib, Pyrazofurin, Indisteron, Phenazone, Aminopyrine, Sulfinpyrazone, Allopurinol, Phenylbutazone, Famprofazone & many other agents. In the present research work, Diethyl malonate & Substituted Hydrazines were reacted together to give pyrazolidine-3,5-dione nucleus which was further derivatized at fourth position by reacting with different aromatic aldehydes to give 4-benzylidene-pyrazolidine-3,5-diones, followed by the 4-chloro & 4-nitrooxy-butyl substitutions at nitrogen atom. The synthesized products were...
 
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