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Homology Modeling of Dopamine Receptors and Docking Study   Manish K. Gupta,Gagandip Singh and Ankit Kumar

Homology Modeling of Dopamine Receptors and Docking Study

80 страниц. 2012 год.
LAP Lambert Academic Publishing
Dopamine receptors (DRs) belong to the class A of G-protein coupled receptors (GPCRs) super family. The five subtypes of dopamine receptors (DRs) i.e. D1R, D2R, D3R, D4R and D5R have been characterized and classified in D1-like (D1R and D5R; stimulatory) and D2-like (D2R, D3R, and D4R; inhibitory) subfamilies based on their sequence similarities and physiological response. The DRs are involved in many physiological processes and thus, deregulation in their activity led to the various mental disorders. Therefore, the DRs are attractive targets for the development of new drug molecules for the treatment of various CNS disorders. This book describes the development and validation of 3D structure model for all DR isoforms. The 3D structure model of DRs may be used in docking study to identify crucial amino acid residues involved Drug-Receptor interactions. This is turn, will contribute in the designing of novel DR agonists and antagonists. This is also helpful to understand the mechanism...
 
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