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Mesenchymal Stem Cells Therapy in Cisplatin-Induced Nephrotoxicity   Hanan Dawood Yassa,Safwat Wadie Gergis and Hassan Abdel Raheem

Mesenchymal Stem Cells Therapy in Cisplatin-Induced Nephrotoxicity

64 страниц. 2013 год.
LAP Lambert Academic Publishing
Stem cell therapy has the future to change the face of human diseases and alleviate suffering. Mesenchymal stem cells (MSCs) have generated a great deal of excitement and promise as a potential source for stem cell-based therapeutic strategies. These data provide the clue of using MSCs in the current work to modulate cisplatin-induced nephrotoxicity, the severest adverse effect of the well-known anticancer drug; cisplatin. Forty adult albino rats were used in this study; MSCs of bone marrow origin were injected into the rat tail vein one day after a single dose of intra-peritoneal injection of cisplatin. Four weeks later, the kidney was examined morphologically, histopathologically and ultra-structurally. Renal functions (urea, creatinine) as well as serum electrolytes levels (Na, K) were estimated. Cisplatin produced marked histopathological changes in rat kidney and impaired renal functions however; MSCs ameliorated cisplatin-induced nephrotoxicity both functionally and...
 
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