Добро пожаловать в клуб

Показать / Спрятать  Домой  Новости Статьи Файлы Форум Web ссылки F.A.Q. Логобург    Показать / Спрятать

       
Поиск   
Главное меню
ДомойНовостиСтатьиПостановка звуковФайлыДефектологияКнижный мирФорумСловарьРассылкаКаталог ссылокРейтинг пользователейЧаВо(FAQ)КонкурсWeb магазинШкольникамКарта сайта

Поздравляем!
Поздравляем нового Логобуржца tatbocman со вступлением в клуб!

Реклама

КНИЖНЫЙ МИР

68Ga-DOTATOC/DOTANOC: synthesis and dosimetry   Durgesh Kumar Dwivedi

68Ga-DOTATOC/DOTANOC: synthesis and dosimetry

92 страниц. 2011 год.
LAP Lambert Academic Publishing
Radiolabeled peptides are of increasing interest in nuclear oncology. In recent years, special emphasis has been given to the development of peptides labeled with positron emitters. Among these, 68Ga deserves special attention as an alternative to FDG, because it is available from an inhouse generator rendering 68Ga radiopharmacy independent of an onsite cyclotron. 68Ga has a half-life of 68 min and decays by 89% through positron emission. The parent, 68Ge, is accelerator produced and decays with a half-life of 270.8 days by electron capture. Several bifunctional chelators based on 1,4,7- triazacyclononane-N,N'',N''''-triacetic acid and 1,4,7,10- tetraazacyclododecane-N,N'',N'''',N''''''- tetraacetic acid (DOTA) macrocycles are available for coupling to peptides and other biomolecules. Clinical studies were performed with 68Ga-DOTA, Tyr3- octreotide, localizing neuroendocrine tumors with higher sensitivity than 111In- diethylenetriaminepentaacetic acid-octreotide. In...
 
- Генерация страницы: 0.04 секунд -