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The immune phenotype of mice deficient for Ly49Q   Marie-Line Goulet

The immune phenotype of mice deficient for Ly49Q

120 страниц. 2011 год.
LAP Lambert Academic Publishing
Plasmacytoid dendritic cells are members of the innate immune system and are particularly important in anti-viral immunity since they are the most potent producers of type I interferons. This book describes the phenotype of knockout mice for Ly49Q, a cell surface receptor expressed on pDCs. In vivo, knockout mice with PGK-Neomycin insertion control early murine cytomegalovirus infection better, but no difference could be detected in mice with recombined LoxP sites. Thus, we observed a differential immune response dependent on the gene knockout strategy. In mice with PGK-Neomycin insertion, we found enhanced hematopoiesis of some populations of the myeloid lineage and lower activation of pDCs following treatment with particular Toll-like receptor ligands, which translates into diminished T cell stimulatory capacity. This suggests a role for Ly49Q in regulating hematopoiesis and pDC activation potential.
 
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