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Potential Drug Delivery Agents for Macromolecular Drugs   Addai-Mensah Donkor

Potential Drug Delivery Agents for Macromolecular Drugs

64 страниц. 2011 год.
LAP Lambert Academic Publishing
The theory and principles of gene delivery for therapeutic function have been well documented. Even though viral vectors, weighed against non-viral vectors such as lipoplexes and polyplexes, are far more competent in bringing about cellular transfection, inherent immunity problem compromise their protective use in vivo. Although vulnerabilities consist of mutational insertion hazard and exposure, potentially leading to oncogenicity, large scale production of viral vectors as such might also represent an impediment. Though less efficient, particularly in vivo, both lipoplexes consisting of a complex of nucleic acids and cationic lipids, and polyplexes, composed of cationic polymers and nucleic acids, are considered to be immunologically inert, and importantly safer than viral vectors for in vivo use. In view of the fact that they are also comparatively easy to produce and to amend chemically for enhancement of transfection efficiency, research efforts in this potential area have been...
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