Добро пожаловать в клуб

Показать / Спрятать  Домой  Новости Статьи Файлы Форум Web ссылки F.A.Q. Логобург    Показать / Спрятать

       
Поиск   
Главное меню
ДомойНовостиСтатьиПостановка звуковФайлыКнижный мирФорумСловарьРассылкаКаталог ссылокРейтинг пользователейЧаВо(FAQ)КонкурсWeb магазинКарта сайта

Поздравляем!
Поздравляем нового Логобуржца Санара со вступлением в клуб!

Реклама

КНИЖНЫЙ МИР

Myocardial stress adaptation: role of hyperlipidemia   Gabriella F. Kocsis,Peter Ferdinandy and Tamas Csont

Myocardial stress adaptation: role of hyperlipidemia

60 страниц. 2014 год.
LAP Lambert Academic Publishing
We' ve shown for the first time that gene expression pattern is altered in the myocardium of cholesterol-fed mouse in response to ischemic preconditioning. This effect is apparent in the regulation of NO signaling, oxidant producing enzymes, and the mevalonate pathway. Our was the first demonstration in human apoB-100 transgenic mice, that hypercholesterolemia but not hypertriglyceridemia is responsible for the hyperlipidemia-induced, peroxynitrite-mediated cardiac dysfunction, and that increased cardiac NADPH oxidase activity is a major source of increased oxidative stress in hypercholesterolemia. We observed first, that acute lovastatin treatment abolished the infarct size-limiting effect of ischemic preconditioning and that chronic lovastatin treatment attenuated the protective effect of ischemic postconditioning. We've also proposed that acute and chronic lovastatin treatment might modulated the cardioprotective mechanisms through different cellular pathways.
 
- Генерация страницы: 0.04 секунд -