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Pharmacological investigation of four synthetic compounds   Avijit Dey,Md. Hamiduzzaman and Uttom Kumar

Pharmacological investigation of four synthetic compounds

100 страниц. 2012 год.
LAP Lambert Academic Publishing
The four synthetic compounds named Ortho-amino aniline, 2-bromo propyl amine hydrobromide, 3-bromopopyl ammonium bromide and Benzimidazole-2-thiol were evaluated for their pharmacological activity. Evaluation of anti-oxidant activity was done by DPPH free radical scavenging activity. In this investigation, the compound ortho amino aniline showed the highest free radical scavenging activity with IC50 value 0.85?g/ml. At the same time Benzimadazole-2-Thiol also showed strong antioxidant potential having IC50 value 4.18?g/ml. The cyto-toxic activity was evaluated using Brine shrimp lethality bio-assay. Among the supplied compounds only ortho amino aniline and bennzimidazole-2-thiol showed mild cyto-toxic activity compared to the positive standard Vincristine sulfate. The analgesic activity was evaluated using acetic acid induced writhing method. The compounds Benzimidazole-2-thiol and 3-bromopopyl ammonium bromide at a dose of 50 mg/kg showed significant analgesic activity with 37.85%...
 
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