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Ethosomes for Transdermal Delivery   Basavaraj Nanjwade and Mahesh K. Patel

Ethosomes for Transdermal Delivery

164 страниц. 2012 год.
LAP Lambert Academic Publishing
"Ethosomes are soft malleable vesicles composed mainly of phospholipid, ethanol (relatively high concentration) and water. These soft vesicles represents novel vesicular carrier for enhance delivery to / through skin. The size of ethosome vesicles can be modulated from tens of microns to nanometres.” Typically, ethosomes may contain phospholipids with various chemical structures like phosphatidylcholine (PC), hydrogenated PC, phosphatidic acid (PA), phosphatidylserine (PS), phosphatidylethanolamine (PE), phosphatidylglycerol (PPG), phosphatidylinositol (PI), unsaturated PC, alcohol (ethanol or isopropyl alcohol), water and propylene glycol (or other glycols). Such a composition enables delivery of high concentration of active ingredients through skin. Drug delivery can be modulated by altering alcohol: water or alcohol-polyol: water ratio. Some preferred phospholipids are soya phospholipids such as Phospholipon 90 (PL-90). It is usually employed in a range of 0.5-10% w/w. Cholesterol...
 
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