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Solubility Enhancement of Certain Drugs by Solid Dispersion Technique   Vidyadhara Suryadevara,Sasidhar Reddyvalam Lankapalli and Ramu Anne

Solubility Enhancement of Certain Drugs by Solid Dispersion Technique

228 страниц. 2014 год.
LAP Lambert Academic Publishing
Recent advances in novel drug delivery systems (NDDS) aim to enhance safety and efficacy of drug molecules by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach was fast dissolving tablets which have gained acceptance and popularity in the recent time. Several pharmaceutical industries prepared fast dissolving tablets by direct compression technique by selecting suitable super disintegrants. Direct compression technique offers important advantages such as increased output, reduced cost, less machinery and improved drug stability compared to wet granulation method.The aim of the work is to enhance the solubility, dissolution rate and oral bioavailability of poorly soluble drugs lovastatin and simvastatin by formulating them as solid dispersions using various techniques with PEG-6000 as a carrier and subsequent preparation of fast dissolving tablets with the prepared solid dispersions using different concentrations of...
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