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Development of Sustained Release Tablet containing Antidiabetic Agent   Rajat Kharche

Development of Sustained Release Tablet containing Antidiabetic Agent

124 страниц. 2013 год.
LAP Lambert Academic Publishing
The overall objective of the present work was to develop an oral sustained release Metformin tablet prepared by direct compression method using Hydroxypropylmethyl cellulose and Xanthan gum in different proportions. Nine formulations (T1-T9) were prepared. All the batches were evaluated for thickness, weight variation, hardness, and drug content uniformity and in vitro drug release. The dissolution study was performed as per USP-32 NF-27. The initial burst release was minimized by optimizing the concentration of xanthan gum. Then the concentration of HPMC was varied, keeping the concentration of xanthan gum fixed. From the dissolution study of nine batches, T8 was found to be the optimized batch capable to sustain the drug release for 10 hrs as it follows the dissolution parameter mentioned in USP-32 NF-27. The drug release kinetics shows that the T8 batch followed first order kinetics.
 
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