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HIV Genetics Evaluation And Viral Dynamics   Dhairya Y. Joshi,Bhuvan P. Raval and Ashok L. Ganure

HIV Genetics Evaluation And Viral Dynamics

60 страниц. 2011 год.
LAP Lambert Academic Publishing
There are the two type of HIV mainly they are HIV-1 and HIV-2. HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients. genetic variation and evolution in the pol gene was studied, with special interests in resistance-associated mutations in HIV-2 infected patients failing antiretroviral treatment. There is observation in some mutations known to cause resistance in HIV-1 such as M184V, Q151M and E219D; but most resistance mutations appeared to differ from what is known in HIV-1. The main conclusion from this work is that specific algorithms for HIV-2 resistance interpretation are needed, because the algorithms for HIV-1 cannot be used. They were studied the evolution of co-receptor usage, neutralization escape and env gene sequence. It is reported that a switch from CCR5 to CXCR4 using virus during disease progression. They did not see a clear pattern of neutralization escape as is...
 
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