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Simvastatin Solid Dispersion Prepared By Microwave Fusion Technique   Haresh Chaudhary,B.N. Patel and D.M. Patel

Simvastatin Solid Dispersion Prepared By Microwave Fusion Technique

124 страниц. 2014 год.
LAP Lambert Academic Publishing
Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion.
 
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