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Amino Acid Derivatives as Novel Non-Steroidal Anti-Inflammatory Drugs   Usama H. Ramadhan

Amino Acid Derivatives as Novel Non-Steroidal Anti-Inflammatory Drugs

140 страниц. 2012 год.
LAP Lambert Academic Publishing
The nature of inflammation and relationship with metabolism of unsaturated fatty acid, and the factors effect on it were shown in this book. The non-steroidal anti-inflammatory drugs (NSAIDs) have side effects and non specific even that specific for cyclooxygenase-2 (COX-2) enzyme, amino acids derivatives were synthesised and tested for anti-inflammatory and analgesic activity. The nature of binding of compounds with the active site of enzyme specify the activity of drugs, they appeared highly activity and high-quality for used as novel anti-inflammatory drugs, without side effects. The histidine derivatives show potent activity as a new anti-inflammatory and analgesic analogue, also tryptophan derivatives they more powerful than aspirin and diclofenac, they contain imidazole ring in their structure. The future of anti-inflammatory drugs (NSAIDs) is amino acids derivatives, and possibly works as anti-cancer drugs.
 
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