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Modernising the Monograph for Cetomacrogol Cream BP 1980, Formulation A   Ameya Pachhade

Modernising the Monograph for Cetomacrogol Cream BP 1980, Formulation A

56 страниц. 2013 год.
LAP Lambert Academic Publishing
A monograph for cetomacrogol cream has been omitted from the British Pharmacopoeia (BP) since 1980. Products containing this cream as a base are still available on the market, for example Bactroban cream®. Hence, there is a need to update monograph for cetomacrogol cream. For this purpose Cetomacrogol Cream BP, formula A was analysed with different test methods. The BP formula B was not available commercially for comparison. This cream was tested for various parameters: appearance, texture, pH value, melting and freezing points, sulphated ash value, and viscosity. It has been found that these tests show useful results and should be included in a new monograph. Results obtained show relevance to use in determining storage conditions, which can be incorporated on the label of this product. Attempts to determine quantitative analysis using HPLC-UV, HPLC-MS and UV- spectroscopy showed no useful results. The reasons behind this can be absence of aromatic group in cream detectable by UV...
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