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Dry Powder for Inhalation   Nutan Shah and Jyoti Waghmare

Dry Powder for Inhalation

144 страниц. 2011 год.
LAP Lambert Academic Publishing
Nowadays, pulmonary delivery tends to be considered as an attractive and promising route for the administration of active substances intended to treat local pulmonary (e.g. asthma, COPD etc.), as well as systemic diseases (e.g. diabetes). Traditional DPI formulations associate the use of micronized drug, usually 2-5 µm in diameter, such formulations deliver around 10-15 % of the drug loaded to the desired target within the lung bronchi. A significant disadvantage of many existing inhaled drugs is the relatively short duration of resultant clinical effects and most medications in aerosol form require inhalation at least 3-4 times daily. This may often lead to poor patient compliance with the therapeutic regime and increase the possibility of associated side effects due to the risk of self administration of the drug by the patients. Sustained release of such drugs in the lung would be particularly beneficial since they could be delivered to and retained at the targeted receptors for a...
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