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Anxiolytic Effect Of 6-Shogaol In Mice   Neelam Yadav

Anxiolytic Effect Of 6-Shogaol In Mice

108 страниц. 2013 год.
LAP Lambert Academic Publishing
The purpose of this study was to demonstrate the anxiolytic-like effects of 6-Shogaol obtained from Ginger root(Zingiber officinale Roscoe, Zingiberacaceae) in mice using various behavioral paradigms.Goups of mice treated with doses of 6-Shogaol 20 mg/kg (i.p.) and 30 mg/kg(i.p.) and diazepam 1 mg/kg( i.p.) did not show any significant effects on locomotion. The same treatment increased in the percentage of time and entries into open arms of the elevated plus maze (EPM). 6-Shogaol at the doses of 20 and 30 mg/kg and DZ (1 mg/kg) induced a significant increase in the time spent in the light box without affecting other parameters. Same treatment induced a significant increase in the head dip counts and head dip duration which was similar to standard dose without affecting locomotion (no. of squares crossed). The aim of the current study was to screen the anxiolytic effect of 6- Shogaol in experimental models of anxiety in mice. The major active ingredients of ginger (6-Shogaol)...
 
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