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Formulation And Evaluation Of Cinnarizine Floating Tablets   Sumit Doshi and Uma Patil

Formulation And Evaluation Of Cinnarizine Floating Tablets

144 страниц. 2012 год.
LAP Lambert Academic Publishing
Cinnarizine, a piperazine derivative with anti-histaminic activity finds its major use in control of vomiting due to motion sickness. It has a short half-life of 3-6 hrs. & the usual dosage regimen is 75 mg twice or three times a day for adults. The floating tablets of cinnarizine were formulated using varying concentration of HPMC K4M & effervescent agents by wet granulation technique. The granules were evaluated for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio & drug content. The tablets were evaluated for thickness, hardness, weight variation test, friability, in vitro buoyancy & in vitro dissolution study. A 3 Square factorial design was used to study the effect of HPMC K4M & citric acid on lag time, floating time & percentage cumulative release. The responses were analyzed using ANOVA & by the predictive equation, it was found that the concentration of HPMC K4M & citric acid significantly affected all the response parameters. The obtained model was...
 
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