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Synthesis and Antibactarial Evaluation Novel Triazol Derivatives   Chirag J. Patel,Vidyasagar Gali and Patel Pratik

Synthesis and Antibactarial Evaluation Novel Triazol Derivatives

88 страниц. 2013 год.
LAP Lambert Academic Publishing
Heterocycles bearing a triazole ring residue are reported to show anticancer, anti-inflammatory, analgesic, antifungal, antitubercular, antimicrobial, antiviral, antioxidant, CNS depressant, and plant growth regulatory activity etc. Keeping in view the importance of Triazole from the literature survey I found various triazole derivatives & from that I planned to work the substituted triazole derivatives from m-nitro benzoic acid, which gives various anticipated biological activities. Among the all synthesized compound, compound 6-(2-chloro-phenyl)-3-(4-nitro-phenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (PLP 105b) with MIC value of (16µg/ml) against gram-positive (B.subtilis) and (16µg/ml) against gram-negative (E.coli,p.aeroginosa)and the compound3,6-bis-(4-nitro-phenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (PLP 105d) with MIC value of (16µg/ml) against gram-negative (p.aeroginosa) give better antimicrobial activity than other synthesized compound.
 
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