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Evaluation of Triterpenoidal Anti-Inflammatory Principle   VICHITRA KAUSHIK,Versha Parcha and Ratan Lal Khosa

Evaluation of Triterpenoidal Anti-Inflammatory Principle

84 страниц. 2011 год.
LAP Lambert Academic Publishing
A triterpenoidal compound (P2) has been isolated from anti-inflammatory activity guided fractionation of acetone extract of Drypetes roxburghii leaf with a gradient of methanol in chlroform. Further P2 was screened for anti-inflammatory activity on carageenan and dextran induced inflammation models in rats at the dose level of 50 mg/kg body weight. Treatment of inflammed rats with P2 has showed significant reduction in inflammation caused by carrageenan (P>0.01) and dextran (P>0.05). Hence P2 can be considered as the active component responsible for the anti-inflammatory activity of Drypetes roxburghii leaf. The characterization of P2 was done by spectral studies like IR, 1H-NMR, 13C-NMR & Mass Spectroscopy. On the basis of spectral studies the structure of P2 has been elucidated as triterpenoidal compound.
 
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