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Synthetic methods, chemistry and anticonvulsant screening of indoles   Md Shamsher Alam and Nadeem Siddiqui

Synthetic methods, chemistry and anticonvulsant screening of indoles

164 страниц. 2013 год.
LAP Lambert Academic Publishing
Clinically available drugs (95%) for epilepsy treatment were approved before 1985 and they could provide satisfactory seizure control for 60-70% of the patients. These drugs however also cause notable adverse side effects and have life-threatening conditions. Thus, there is constant need for compounds with improved neuropharmacological activities with lower toxicities. Research to find more effective and safer antiepileptic drugs are therefore imperative and challenging in medicinal chemistry. Indole and its derivatives are used in organic synthesis and they are used in evaluating new product that possess different biological activities. Several newer benzfused five membered heterocyclic derivatives based on the pharmacophore models are intended to be synthesized which are expected to possess better anticonvulsant activity with lower neurotoxicity. It is hoped that this book will have wide appeal for undergraduates, postgraduates, and practitioners in the health sciences (e.g.,...
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