Добро пожаловать в клуб

Показать / Спрятать  Домой  Новости Статьи Файлы Форум Web ссылки F.A.Q. Логобург    Показать / Спрятать

       
Поиск   
Главное меню
ДомойНовостиСтатьиПостановка звуковФайлыКнижный мирФорумСловарьРассылкаКаталог ссылокРейтинг пользователейЧаВо(FAQ)КонкурсWeb магазинКарта сайта

Поздравляем!
Поздравляем нового Логобуржца bagira со вступлением в клуб!

Реклама

КНИЖНЫЙ МИР

Ivermectin for alcohol use disorders   Sheraz Khoja

Ivermectin for alcohol use disorders

96 страниц. 2014 год.
LAP Lambert Academic Publishing
Alcohol use disorders (AUDs) ranks third on list of preventable causes of morbidity and mortality in United States. AUDs has a major national impact affecting over 18 million people. The increasing prevalence of AUDs coupled with the limited efficacy of FDA approved drugs implies the huge medical unmet need for these disorders. Recent genomic studies have demonstrated that the purinergic P2X4 receptors (P2X4Rs) might be a target for alcohol. Alcohol has inhibitory effect on P2X4Rs and this might to contribute to some of alcohol induced cellular and behavioral effects. Moreover, ivermectin (IVM),a FDA approved antiparasitic agent was shown to antagonize ethanol induced inhibition of P2X4Rs.Hence, my hypothesis was that IVM may represent a novel therapy for AUDs. The first chapter focuses on effect of IVM on alcohol intake using multiple alcohol drinking paradigms in mice while second chapter focuses on investigating effect of IVM on various aspects of behavior related to emotion and...
 
- Генерация страницы: 0.02 секунд -