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Solid Dispersion Of Aceclofenac And B-Cyclodextrin Complex   Khushal Dhamat,Nirmal Shah and Chirag Bhalala

Solid Dispersion Of Aceclofenac And B-Cyclodextrin Complex

92 страниц. 2012 год.
LAP Lambert Academic Publishing
Aceclofenac is an effective analgesic and anti-inflammatory drug prescribed widely in recent years for various types of pain and inflammation. Aceclofenac is partially insoluble in water and aqueous fluid and as such it exhibits poor variable oral bioavailability. Aceclofenac needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. Among the various approaches to enhance the solubility and dissolution rate of poorly soluble drugs complexation with cyclodextrin is an effective and industrially accepted technique. In the present investigation, Complexation of aceclofenac with ?-CD was carried out by using various techniques like physical mixture, kneading method, co-precipitate method & solvent evaporation method. From the various characterization studies like drug content, production yield & in vitro dissolution study. Data were further treated with statical analysis using ANNOVA model and from the result of statical analysis...
 
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