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КНИЖНЫЙ МИР

Formulation and Evaluation of Glipizide Solid Dispersion   M.R. Shivalingam,G. Durgabhavani and K.S.G. Arulkumaran

Formulation and Evaluation of Glipizide Solid Dispersion

84 страниц. 2013 год.
LAP Lambert Academic Publishing
More than 90% of the drugs arrowed since 1995 have poor solubility, poor permeability and more than 40% of new chemical entities have little or no water solubility. Glipizide is a class-II drug which is poorly soluble. So the solubility of the drug is enhanced by solid dispersion using solvent evaporation method. Drug and carrier in different ratios like 1: 1, 1: 2, 1: 3 by keeping drug weight constant. The prepared solid dispersions were evaluated for their routine tests like Phase solubility, Invitro dissolutoion study and the results were observed and tabulated. FT-IR study was also done for drug, polymers and 1: 3 ratios of drug: carrier by KBr pelleting method. From the study it was confirmed that no physical interactions were found. Also from the study it was concluded that 1: 3 ratio of drug:carrier shows better phase solubility and invitro dissolution rate.
 
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