112 страниц. 2012 год. LAP Lambert Academic Publishing The basic characteristic of oral controlled release system is to produce therapeutically efficacious blood levels in a constant controlled manner over a long duration. One of the technique is modified oral devices, the rate of drug absorption determination be adjusted through a controlled rate of drug release from the matrix core layered with a swellable polymer by modulating the drug release. These systems can be developed on large scale using layered tablet press.