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Fast Dissolving Tablets Of Chlorpromazine And Promethazine   Gudas Ganesh Kumar,R. Umamaheshwari and D. Bhikshapathi

Fast Dissolving Tablets Of Chlorpromazine And Promethazine

116 страниц. 2012 год.
LAP Lambert Academic Publishing
Chlorpromazine HCl and Promethazine HCl are potent anti-emetic. The central antimuscarinic actions of antihistamines are probably responsible for their anti-emetic effects. Fast dissolving tablets of Chlorpromazine HCl and Promethazine HCl were prepared using five superdisintegrants viz; sodium starch glycolate, crospovidone, croscarmellose, L-HPC and pregelatinised starch. The tablets were evaluated for weight variation, hardness, friability, disintegration time (1 min), dissolution rate, content uniformity, and were found to be within standard limit. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants. Among the different formulations of Chlorpromazine HCl and Promethazine HCl was prepared and studied and the formulation F2 and S2 containing crospovidone, mannitol and microcrystalline cellulose combination was found to be the fast dissolving formulation. In the present...
 
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