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Synthesis and QSAR Study of Benzimidazole Derivatives   Gayatri Suryawanshi,Rajendra Doijad and Vitthal Kulkarni

Synthesis and QSAR Study of Benzimidazole Derivatives

188 страниц. 2012 год.
LAP Lambert Academic Publishing
Life threatening infections caused by pathogenic fungi are becoming increasingly common, especially in individuals with suppressed immune systems. However, there are only a limited number of antifungal drugs available for such infections, which leads to a strong need to develop new classes of compounds having antifungal activity. From the literature survey; it was found that there has been a lot of research going in the field of novel antifungal drug development. It was found that many antifungal agents contain benzimidazole moiety in their structure. Therefore benzimidazole was selected for the development of new chemical entities as potential antifungal agents. Fifteen derivatives of benzimidazole were synthesized using different substituted phenol as a side chain. Synthesized compounds were characterized by chromatographic methods, Infrared spectroscopy and Nuclear Magnetic Resonance spectroscopy for their structural confirmation. These compounds were tested for antifungal...
 
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