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Microcephaly: Clinical and Epidemiological Studies   Ghada Abdel-Salam and Andrew Czeizel

Microcephaly: Clinical and Epidemiological Studies

276 страниц. 2011 год.
LAP Lambert Academic Publishing
Microcephaly (congenital-postnatal, primary- secondary, isolated-multiple) is a heterogeneous congenital abnormality from clinical, pathogenetical and etiological aspects. We re- evaluated 82 patients with microcephaly. Patients were classified pathogenetically into primary and secondary and morphologically into isolated; and multiple congenital abnormalities associated with microcepahly. This study demonstrated the clinical, neurologic, anthropometric features,recurrence risk and prenatal diagnosis for the different subgroups of microcephaly. Further, It presented the association of epilepsy,the EEG changes and control to anti-epileptic drugs with the different groups of microcephaly. We believe that the use of such classification will help in understanding, dealing with this heterogeneous disorder, application of the molecular testing and genetic counseling. In addition, this population-based study showed that the high parity, the low socio-economic status, the...
 
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