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The added value of natural killer cells in immunotherapy for leukemia   Eva Lion,Evelien Smits and Viggo Van Tendeloo

The added value of natural killer cells in immunotherapy for leukemia

260 страниц. 2012 год.
LAP Lambert Academic Publishing
The ultimate goal of tumor immunotherapy is the eradication of tumor cells by the immune system. Both innate and adaptive immune responses can contribute to the elimination of tumor cells, with natural killer (NK) cells and T lymphocytes as pivotal players, respectively. Dendritic cells (DC) are the most professional antigen-presenting cells of the immune system, bridging innate and adaptive immune responses through interaction with NK cells and presenting tumor-associated antigens to T cells. A major hurdle in anti-tumor immunity, however, is the low immunogenicity and immunosuppressive character of tumor cells resulting in an immunotolerant environment. Here, the primary scope was to increase the immunogenicity of leukemic cells by introducing a danger signal to break immune tolerance. We clearly demonstrate that transfection of leukemic cells with the synthetic double-stranded RNA agonist poly(I:C) provides a way to overcome immune evasion, evidenced by their enhanced capacity to...
 
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