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Advanced glycation inhibitory potential of certain antidiabetic plants   Amteshwar Jaggi,Varun Parkash and Nirmal Singh

Advanced glycation inhibitory potential of certain antidiabetic plants

64 страниц. 2014 год.
LAP Lambert Academic Publishing
The present study was designed to investigate the antiglycation potential of hydro-alcoholic and alkaloidal fractions of selected plants. Seeds of Trigonella foenum-graecum, bulbs of Allium sativum, fruits of Momordica charantia. and leaves of Gymnema sylvestre were selected. The protein glycation inhibitory activity of these plants was evaluated using glucose-bovine serum albumin assay. Among the hydroalcoholic extracts, Trigonella-foenum graecum showed highest antiglycation activity (IC50 = 53.53 ± 1.24 µg/ml) followed by Allium sativum (IC50 = 68.36 ± 1.56 µg/ml), Momordica charantia (IC50 = 85.16 ± 1.87 µg/ml) and Gymnema sylvestre (IC50 = 103.66 ± 2.09 µg/ml). Among the alkaloidal fractions, the highest antiglycation activity was shown by Trigonella-foenum graecum (IC50 = 31.56 ± 1.36 µg/ml) followed by Allium sativum (IC50 = 40.46 ± 1.59 µg/ml), Momordica charantia (IC50 = 54.8 ± 2.12 µg/ml) and Gymnema sylvestre (IC50 = 64.50 ± 1.73 µg/ml). Aminoguanidine, a standard drug,...
 
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