64 страниц. 2012 год. LAP Lambert Academic Publishing 1. Introduction ¦ Types of reactive oxygen species (ROS) ¦ Sources ¦ Structure ¦ Mechanism of ROS generation ¦ p53,oxidative stress and ROS. 2. Oxidative stress and free radical damage ¦ Oxidative lipid damage ¦ Oxidative DNA damage ¦ Oxidative protein damage ¦ Role of ROS in cell signaling ¦ Aberrant regulation of redox-sensitive signal pathway ¦ Molecular mechanism of age-related diseases. 3. Antioxidant defense ¦ Antioxidant therapy ¦ Oxidative modification of protein and possible biomarkers. 4. Specific pathways transduced by ROS and ROS-induced apoptosis will provide opportunities to impact both life span, Age related-diseases and design the chemotherapeutics for humans.