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Molecular Cytogenetics of XLMR in Idiopathic Severe Mental Retardation   Shivani Kachroo and Minakshi Vashist

Molecular Cytogenetics of XLMR in Idiopathic Severe Mental Retardation

384 страниц. 2014 год.
Scholars' Press
Mental retardation is a common and distressing disorder that affects 3% of the population. It is a clinically and etiologically heterogeneous group of conditions. It is among one of the major disorders that are still poorly understood in terms of etiopathogenesis and for which very little therapeutic help is provided. Poor understanding of its origins hampers the provision of effective treatment and preventive regimens therefore mental retardation remains a major challenge for medical practice.It could be due to combination of genetic and environmental factors. As Fragile X is the biggest reason behind X linked mental retardation hence it might be a significant contributor to idiopathic mental retardation. Because of unique structural and functional characteristics of telomere associated sites such as in XLMR (FRX), its difficult to find the locus of mutation by conventional cytogenetics. Hence molecular techniques may be useful. Determining a...
 
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