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Tumor suppressor gene activity in lung, colon and breast carcinomas   EDWARD ESPLIN

Tumor suppressor gene activity in lung, colon and breast carcinomas

80 страниц. 2010 год.
LAP Lambert Academic Publishing
The most common cancers of adults include lung, colon and breast carcinoma. The PP2A-A? gene (PPP2R1B) encodes a component of protein phosphatase 2A. The important role of protein phosphatase 2A in down regulating cell growth and the mutations of PP2A-A? in many human cancers suggest PP2A-A? is a tumor suppressor gene. Screening of cancer patient DNAs revealed alterations of PP2A-A? in various cancers and a germline alteration associated with breast carcinoma. Biochemical studies showed mutations in PP2A-A? reducing its ability to bind the PP2A complex. Transfecting the PP2A-A? gene into cancer cell lines conferred a relative growth disadvantage to transfected cells. Cell lines expressing exogenous PP2A-A? are found to have lower levels of ?-catenin, suggesting the PP2A-A? gene is involved in regulating the Wnt signaling pathway. These studies elucidate the tumor suppressor qualities of the PP2A-A? gene, its role in heritable cancer susceptibility, the potential it has as a target...
 
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