232 страниц. 2010 год. LAP Lambert Academic Publishing The underlying theme of this doctoral thesis was • To evaluate the role of genetic aberrations in different signal transducing molecules of important signal transduction pathways that are involved in the development and progression of CRC in Kashmiri population. • To assess the possible association between the genetic aberrations of the signal transducing molecules and various life style factors that are likely to lead to the development and progression of colorectal cancer. • To observe the significance of multistep model of CRC carcinogenesis in explaining the CRC carcinogenesis in our Kashmiri population. After assessing the various signal transducing molecules for genetic aberrations we found that the multi-step model of CRC carcinogenesis holds well in explaining the CRC tumorigenesis in our Kashmiri population but with a slight difference in manner and frequency of genetic aberrations of key tumor suppressor genes and oncogenes.