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Acute lymphoblastic leukemia (ALL) and interferon beta-1 gene   Madiha Kanwal,Muhammad Jawad Khan and Abdul Rauf Shakoori

Acute lymphoblastic leukemia (ALL) and interferon beta-1 gene

172 страниц. 2012 год.
LAP Lambert Academic Publishing
Acute lymphoblastic leukemia (ALL) is a malignant disease caused by the abnormal growth and development of early non-granular white blood cells, or lymphoblasts. ALL occurs predominantly in children, peaking at 4 years of age. Interferons (IFNs) are the biological agents involved in the antiviral responses and the inhibition of tumor growth. In oncology, the IFNs are an important treatment options for a number of solid tumors and hematological malignancies. The IFN-?1gene consists of 840 bp and it lacks intron sequences. Seventy patients suffering from Childhood Acute Lymphoblastic Leukemia were studied and analyzed for mutation analysis of IFN-?1. So, 58.3% of the patients suffering from ALL were observed and compared with 41.7% normal DNA samples as control. PCR was performed and amplified gene products were detected on agarose gel and PAGE. Finally, SSCP was performed and mobility shift was observed in 7 out of 70 ALL samples. We observed that ALL disease typically develops in...
 
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