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Molecular Mechanisms of Cardiac Hypertrophy and Heart Failure   Thomas von Lueder

Molecular Mechanisms of Cardiac Hypertrophy and Heart Failure

56 страниц. 2011 год.
LAP Lambert Academic Publishing
Heart failure (HF) is a major cause of death worldwide. Remodeling of the heart plays an important role in the development of HF. Activiation of the vasoconstrictor endothelin-1 (ET-1) in HF has multiple adverse effects on the cardiovascular system. Dr. von Lueder et. al. identified the lungs as a major source of increased ET-1 levels in a HF model. Pulmonary congestion increased the number of inflammatory cells as well as ET-1 production. When HF animals were treated with a macrophage blocker in follow-up experiments, ET-1 levels were reduced and, importantly, cardiac function improved. Important aspects of cardiac function are controlled by G protein-coupled receptors (GPCR). GPCR signaling is shut off by a small group of enzymes called GRKs. In genetically-engineered mice (GRK3ct), GRK3 inhibition enhanced cardiac function, presumably through continuous ?-adrenergic signaling. Importantly, GRK3ct mice were prevented from HF when subjected to sustained severe cardiac stress for up...
 
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